Diabetes: Keeping Your Blood Sugar at Healthy

People with diabetes should keep their blood sugar (also called blood sugar) at a healthy level to prevent or slow down diabetes problems. Ask your doctor or diabetes teacher what a healthy blood sugar level for you.

* You can get the blood sugar too high if you eat too much. If your blood sugar becomes too high, you may be sick.
* Your blood sugar can also go too high if you do not take the right amount of diabetes medicine.
* If your blood sugar remains high, especially for long periods of time, you can get diabetes problems. Problems that can occur include injury to the heart, eyes, feet, kidneys, and other problems.
* You can also hurt if the blood sugar becomes too low.

How Can I Keep My Blood Sugar Level in Healthy?

* Eat about the same amount of food each day.
* Eat your food and snacks at around the same time every day.
* Do not skip meals or snacks.
* Take your medicines at the same time every day.
* Exercise around the same time every day.

Why Should I Eat About the Same Amount Each Day?

* The food you eat turns into sugar and travels to your blood. This is called blood sugar. Your blood sugar goes up after you eat.
* Keep your blood sugar at a healthy level by eating about the same amounts of food at about the same times each day.
* Your blood sugar will not stay at a healthy level if you eat a big lunch one day and a small lunch the next day.

Why Should I Eat at About the Same Times Each Day?

* Eating at about the same times each day helps you keep your blood sugar from getting too high or too low.
* Eating at about the same times each day also helps your diabetes medicine keep your blood sugar at a healthy level.

What Times Should I Take My Diabetes Medicines?

* Talk with your doctor or diabetes teacher about the best times to take your diabetes medicines. Fill in the names of your diabetes medicines, when you should take them, and how much you should take.

Here are some hints:

* Diabetes pills: Take these before you eat.
* Regular, NPH, or Lente insulin: Take this 30 minutes before you eat.
* Humalog insulin lispro: Take this just before you eat.

Points To Remember

The food you eat makes your blood sugar go up. Diabetes medicines make your blood sugar go down. Together, when each is taken properly, they help you keep your blood sugar at the healthy level.

That's why you should:

* Eat about the same amounts of food each day.
* Eat your meals and snacks at about the same times each day.
* Try not to skip meals and snacks.
* Take your diabetes medicines at about the same times each day.
* Exercise at about the same times each day.

Keeping your blood sugar at a healthy level every day can helps you to prevent diabetes problems.
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How Dangerous Is Swine Flu?

Experts say it is difficult to say at this time. In Mexico people infected have died, while all have been back in the other countries. There are reports that the symptoms of infection are people outside of Mexico milder, compared to some cases in Mexico.

Antivirals such as Tamiflu, has been shown to be very effective in treating patients infected with swine flu. Most developed countries have large shares this antivirals. English, for example, have enough antivirals to treat 35 million people - more than half the country's total population. Prime Minister Gordon Brown has announced a stock will increase so that 50 million people can be treated.

Why have people died of swine flu in Mexico but not in other countries?

Nobody is sure. Any of these factors could play a part:

  • Mexicans who died may have sought treatment at a much later stage, compared to those in other countries.
  • All the other countries so far are highly developed industrialized countries.
  • General living conditions and nutritional standards of those who died in Mexico may have been lower, compared with those who survived in Mexico and abroad.
  • The possibility that there may be two viruses circulating - a mild one and a more virulent one - has not been discounted yet.
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A New Way Of Treating The Flu, Both The H And N Portions Are Targeted

What happens if the next major influenza mutation proves resistant to available anti-viral drugs? This question is now presenting itself to scientists and health officials this week at the World Health Assembly in Geneva, Switzerland, as they continue to do battle with H1N1, the so-called swine flu, and prepare for the next iteration once - change the flu virus.

Promising new research announced by Rensselaer Polytechnic Institute could provide entirely new tools to fight the flu. Discovery, which is a one-two punch against the disease that targets the disease on two fronts, going one step more important than the currently available flu drugs.

"We have been fortunate with H1N1 because it has been responding well to available drugs. But if the virus mutates substantially, the currently available drugs might be ineffective because they only target one portion of the virus," said Robert Linhardt, the Ann and John H. Broadbent Jr. '59 Senior Constellation Professor of Biocatalysis and Metabolic Engineering at Rensselaer. "By targeting both portions of the virus, the H and the N, we can interfere with both the initial attachment to the cell that is being infected and the release of the budding virus from the cell that has been affected."

The findings of the team, which have broad implications for future flu drugs, will be featured on the cover of the June edition of European Journal of Organic Chemistry.

The influenza A virus is classified based on the form of two of its outer proteins, hemagglutinin (H) and neuraminidase (N). Each classification - for example H5NI "bird flu" or H1N1 "swine flu" - represents a different mutation of hemagglutinin and neuraminidase or H and N.

Flu drugs currently on the market target only the neuraminidase proteins, and disrupt the ability of the virus to escape an infected cell and move elsewhere to infect other healthy cells. The new process developed by Linhardt is already showing strong binding potential to hemagglutinin, which binds to sialic acid on the surface of a healthy cell, allowing the virus to entire the cell.

"We are seeing promising preliminary results that the chemistry of this approach will be effective in blocking the hemagglutinin portion of the disease that is currently not targeted by any drug on the market," he said.

In addition, Linhardt and his team have shown their compound to be just as effective at targeting neuraminidase as the most popular drugs on the market, according to Linhardt.

The approach can also be modified to specifically target the neuraminidase or the hemagglutinin, or both, depending on the type of mutation that is present in the current version of the flu, according to Linhardt.

In the next steps of his research, Linhardt will look at how their compounds bind to hemagglutinin, and he will test the ability to block the virus first in cell cultures and then in infected animal models.

"It is still early in the process," he said. "We are several steps away from a new drug, but this technique is allowing us to move very quickly in creating and testing these compounds."

The technique that Linhardt used is the increasingly popular technique of "click chemistry." Linhardt is among the first researchers in the world to utilize the technique to create new anti-viral agents. The process allows chemists to join small units of a substance together quickly to create a new, full substance.

In this case, Linhardt used the technique to quickly build a new derivative of sialic acid. Because it is chemically very similar to the sialic acid found on the surface of a cell, the virus could mistake the compound as the real sialic acid and bind to it instead of the cell, eliminating the connections to hemagglutinin and neuraminidase that are required for initial infection and spread of the infection in the body. The currently available drugs are translation-state inhibitors whose chemical structure allows them to only effectively target the neuraminidase.

The research was funded by the National Institutes of Health. Linhardt was joined in the research by Michel Weïwer, Chi-Chang Chen, and Melissa Kemp of Rensselaer.
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Avian Influenza Virus: Mechanism, Epidemiology And Control

Early 2009, eight cases of human H5N1 infections is very pathogenic avian influenza (HPAI) virus, with 5 cases of death, were reported in China. This again makes the sign of the possible pandemic in the world, may be caused by avian-origin influenza virus. More H5N1 is in the spotlight in the world, not only for scientists but also for ordinary people. How much we know about this virus. Where the virus will go and where they come from? We can avoid the possibility of pandemic influenza. Human will conquer this agent is effective? Of course, we can from our list of questions to find out answers.

Influenza virus, as a pathogenic entity for the chickens, has been known since 19th century. But in 1997, the first cases of human infection with the death and identified as the H5N1 virus strain found in Hong Kong SAR (Special Administrative Region), China, reminds us of virus-host is extending its reach from birds to mammalians. In 2003, when the outbreak of SARS (Severe acute respiratory syndrome), a fatal human case is diagnosed with a surprising isolation of H5N1 virus. This is the first human infection case in mainland China. Now we know many countries (15 countries to early 2009) there is the human H5N1 influenza virus infection. These countries have been the epicenters of the influenza virus, including in addition to seasonal influenza virus H5N1. In 2005, even natural reservoir host, move the birds found infected with the epidemic more than 6,000 dead birds that are involved. Therefore, the special in this topic, we invite scientists from Hong Kong and mainland China recently to review progress in the H5N1-related research field with seven reviews and one script in the original study endocytosis and H5N1 influenza virus. Website for the Bird Flu Information consisting of avian influenza information from the various aspects are also introduced. This is not only a database and a platform for researchers Knowledgebase but also for the community.

First we invited two prominent scientists, Yuelong SHU and Paul CHAN, from China CDC and the Chinese University of Hong Kong respectively to overview the situation of human infection of H5N1 in mainland China and the experience in Hong Kong. They summarize the frontline epidemiological, clinical and virological characteristics of human avian influenza virus infections based on the national surveillance system in mainland China and give a chronological and archival description of the events in Hong Kong. These accounts would greatly be appreciated for the future preparedness of possible pandemics. From the current human reported H5N1 virus infection cases, most of the patients could trace back with contacts of birds (chicken or ducks) though there were some reports with evidence of limited human-to-human transmission. Therefore domestic or wild bird infection control is the key for the H5N1 human infection. Hualan CHEN from Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, discusses the situation of animal infection and its control in China.

As we know, more and more species, especially some mammalian species such as cats and tigers, are becoming victims or carriers of H5N1, the expansion of the host range and interspecies transmission of H5N1 virus is worrying. The mechanism underlying this change is elusive and scientists are working together to tackle this problem from our understanding of the virus itself and the host factors affecting this change. George F. GAO, Frank LIU and colleagues from CAS Key Laboratory of Pathogenic Microbiology and Immunology review our current knowledge of the interspecies transmission and host factors involved: from virus receptor usage to host proteins interacting with the virus or virus components.

Basic research always gives us some tantalizing hope for the control of virus infection. Nucleoprotein (NP) is an important structural protein of influenza virus, being the key component of the ribonucleoprotein complex. The structure of NP is revisited by Andy NG, Jia-Huai WANG and Pang-Chui SHAW from Dana-Farber Cancer Institute and the Chinese University of Hong Kong. Correlations are made between the sequence conservation and the atomic structure. This provides the basis for identifying structurally and functionally important regions for inhibitor design. Crystal structures of some parts of the polymerase complex, PA alone or PA with part of PB1, have been solved. Zihe RAO, Yingfang LIU and colleagues from Institute of Biophysics, CAS, Tsinghua University and Nankai University, provide an overview of the structure and potential target for the new drug design. For a long time the drug target for influenza viruses was basically limited to two proteins, hemagglutinin (HA) and neuraminidase (NA). Hopefully, the basic findings on nucleoprotein and polymerase will lead to some new drug leads.

Clinically the human cases of H5N1 infection manifest some ARDS (acute respiratory distress syndrome) symptoms, similar to SARS infection. Therefore unraveling the molecular pathogenesis mechanism will help save life. Chengyu JIANG, from Peking Union Medical College, Chinese Academy of Medical Sciences, who has long been involved in the study of molecular pathogenesis of SARS, describes our current understanding of the molecular pathogenesis of H5N1 in human infection and presents their recent work on the clathrin-dependent endocytosis of H5N1 influenza virus.

H5N1 virus research is a scientifically fascinating field and a much-needed field for life-saving. In the future we ought to know why and how H5N1 virus expands its host range. Compared to SARS, H5N1 is more complicated. Is there any chance human beings will be in a position to conquer this devastating virus? The understanding of H5N1 virus also helps us to combat other influenza viruses, such as the swine flu that has recently surfaced from Mexico. Though readers would see we have made some progress in the field, this tantalizing record is far from our ultimate goal of control of this virus. Molecular pathogenesis, virus evolution, human immune response and vaccine development, drug discovery and other basic research must be addressed.
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Questions & Answers about Swine Flu

Swine Flu Virus Infections in Pigs
Swine influenza is a respiratory disease of pigs caused by type A influenza viruses and has a major economic impact on the swine industry in the United States. Flu outbreaks in pigs are common, especially during winter months. Swine flu can result in high rates of illness in herds.

• High fevers in infected pigs are common, and can result in reduced fertility or elevated abortion rates among sows.
• Studies have shown that 30% to 50% of commercial U.S. swine have been infected with swine flu.
• Pigs most commonly get infected with flu viruses from other pigs (swine flu), but also can get infected with flu viruses from birds (avian flu), and from people (human flu). This cross-species spread of flu viruses can lead to new types of flu viruses.
• The number of subtypes and strains of flu virus circulating among U.S. herds has complicated swine flu vaccine programs and resulted in increased economic loss from illness in pigs.

Signs of swine flu in pigs may include:

• l coughing (“barking”)
• l discharge from the nose
• l sneezing
• l breathing difficulties
• l going off feed

Questions & Answers about Swine Flu

How does swine flu spread among pigs?
Swine flu viruses are thought to spread mostly through close contact among pigs and possibly from contaminated objects moving between infected and uninfected pigs. Herds with continuous swine flu infections and herds that are vaccinated against swine flu might have sporadic disease, or may show only mild or no signs of infection.

Can swine flu infections be prevented in pigs?
  • Swine flu infections can be potentially prevented by:
  • Vaccinating herds
  • Using good biosecurity measures
  • Encouraging good hygiene practices among workers
  • Using proper ventilation systems

What about flu vaccines for pigs?
Flu vaccines for pigs can help, but are not 100% effective. One reason is that several different strains of flu can infect pigs and vaccines might not protect against all strains.

How can veterinarians help?
Veterinarians can help to develop management strategies to reduce the spread of flu among herds and to prevent the spread of flu viruses between pigs, people, and birds.

Can people catch swine flu from eating pork?
There is no evidence to show that swine influenza can be transmitted through food. Eating properly handled and cooked pork and pork products is safe. Cooking pork to an internal temperature of 160°F kills bacteria and viruses.

What You Can Do
First, wash your hands frequently after exposure to animals and avoid contact with ill appearing animals. If you or your family becomes ill with flu-like symptoms, let your doctor know if you have been around pigs that could have the flu. A nose or throat swab is needed to determine if you might be infected with a swine flu virus.
Most cases of influenza in humans are caused by human flu viruses. However, in the unusual event that you are infected with a swine flu virus, the health department will want to talk with you about your illness and make sure that other people you live and work with are not sick with swine flu. Influenza medications are available to treat swine flu illness in people. These medicines should be started in the first 2 days of being ill to be most effective.

Flu Can Spread from Pigs to People and from People to Pigs
• Swine flu viruses can infect humans, but this is not common.
• Human and swine flu viruses are different. People who get vaccinated for human flu can still get sick from swine flu. Pigs that have been vaccinated for swine flu can still get sick from human flu.
• Symptoms of swine flu in people are no different from symptoms that people get when they are infected with human flu viruses.
• People infected with flu typically have fever (often high), cough, body aches, headaches, fatigue and runny or stuffy nose. Vomiting and diarrhea may also occur.
• Recent studies have shown that 15% to 25% of swine farmers might have been infected with swine flu viruses, as well as about 10% of veterinarians.
• Cases of swine flu have most commonly occurred in people with direct exposure to pigs, but some cases of human-to-human transmission have been reported Read More......

WHO: Prepare to face Influenza pandemic.

Countries in the world at this time are expected to guard over the coming influenza pandemic. That means the plan must continue to do preparedness, the capacity of making the vaccine should be improved, and the stock of antiviral drug production should be.

This is a time that is not stabilized for the nations in all worlds major. The pressure certainly also experienced health ministers. Only one thing can be clear about the virus-the virus is influenza virus-virus behavior that cannot be predicted. No one can say how they are evolving at this time.

Therefore, there are not until the top of the monitor H5N1 apart than guard the H1N1. This virus becomes endemic in some farms in the region. Not yet know how H5N1 will behave.

H5N1 has conditioned us to attitude as if we have a pandemic with high mortality. Diseases such as, of course, cannot be avoided will be pandemic. Read More......

Mexican Flu Infection Case, Already Over 2,000

23 countries have officially reported the incident Mexican flu to the WHO world health body. Around 2099 cases of infection of influenza A (H1N1) recorded. Based on the laboratory examination, Mexico reported 1112 cases with 42 cases died.

United States, based on laboratory examination reported 642 cases including 2 cases died. Several countries reported the occurrence of infection with no other cases died between Austria (1), Canada (201), China, Hong Kong (1), Colombia (1), Costa Rica (1), Denmark (1), El Salvador (2) , France (95), Germany (9), Guatemala (1), Ireland (1), Israel (4), Italy (5), Netherlands (1), New Zealand (5), Portugal (1), Republic of Korea (2 ), Spain (73), Sweden (1), Switzerland (1) and England (28). Read More......
 

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